The research of the Kalsbeek research group is focused on those hypothalamic systems that control metabolism, circulation and the immune system. To unravel the mechanisms of hypothalamic integration we study the hypothalamic biological clock and how it enforces its molecular rhythms onto daily physiology and behaviour.


The hypothalamus rules those things in life that really matter, such as sex and food, and love and aggression. This ‘primitive’ area at the base of the brain controls all aspects of our lives that are of the utmost importance, but at the same time mostly go unnoticed. Together the various hypothalamic nuclei control how we respond to stress, injury and infection. They determine our appetites for food and water, and subsequently regulate how we use the energy that we have taken in. The hypothalamus ensures a stable blood pressure, blood volume, electrolyte balance and body temperature. Last but not least, the hypothalamus imposes daily rhythms, such as the sleep/wake rhythm, onto our bodies. In other words, the hypothalamus controls the rhythm of our life. These things might seem mundane compared to the intangible mysteries of cognition, but they are of immediate and profound importance for our health and well-being. 



A list of the latest publications can be found here.


Is het ongezond om 's avonds laat te eten? Podcast

Tegen de klok in (Parool, 07 augustus 2018) Download

 's Avonds gewond geraakt? Jammer dan (Trouw, 02 december 2017) Download

 vroege vogel of nachtvlinder? (Parool, 26 november 2017) Download

Duisternis wordt een kostbaar goed op aarde (Trouw, 23 november 2017) Download

Nachten worden steeds lichter, besparing en techniek ten spijt (Volkskrant, 22 november 2017) Download

Nobelprijs voor biologische klok (bionieuws, 07 oktober 2017) Download

Een piepklein klokje, maar heel robuust (Trouw, 07 oktober 2017) Download

Nobelprijs voor de jetlag (Het Financieele Dagblad, 07 oktober 2017) Download

Circadian clocks scoop Nobel prize (Nature, 05 oktober 2017) Download

Ontdekkers van de interne klok winnen Nobelprijs (Trouw, 03 oktober 2017) Download

Nobel geneeskunde voor biologische klok (Volkskrant, 03 oktober 2017) Download

Ons dagelijk ritme ontrafeld (NRC, 02 oktober 2017) Download

Timing is everything: U.S. trio earns Nobel for work on the body's biological clock (Science, 02 oktober 2017) Download